Colloquium
Department of Physics, NCU
Cerebroporomechanics in hydrocephalus with aquaporin-4 effect
Speaker
周鼎贏 助理教授 (Prof. Chou, Dean)
中央大學機械工程學系
NCU Department of Mechanical Engineering
Date 2018.10.23 (Tue)
Time 14:00-16:00
Place S4-625
Abstract
For many common neurological disorders, cerebral oedema plays an important role associated with morbidity and death. The typical options of current treatments regimes mainly involve hyperosmolar agents and surgical decompression; these therapies have been utilised for 80 years. Modulating brain water transport via AQP4, which ultimately reduces cerebral oedema, was proposed by Manley et al. in 2000 and was published with experimental results (via a mouse model) in Nature Medicine. Since AQP4 on glial cells is highly related with the glymphatic system due to the end-feet regulating water via AQP4 channels, the water mobility in the glymphatic system/ PVS/ ISF compartment and AQP4-deficient expression in the glymphatic system/PVS/ISF compartment are manipulated as well in order to confirm this alleviated cerebral oedema hypothesis.