Colloquium
Department of Physics, NCU
Examples in Nanoparticles Facilitated cancer Theragnostic Strategy: The non-invasive advantages of spectroscopy in nanobiotechnology
Prof. Chia-Liang Cheng (鄭嘉良)
Department of Physics, National Dong Hwa University
Date 2022.05.03 (Tue)
Place S4-625
Time 14:00-16:00
Abstract :
Spectroscopic techniques, such as Infrared, Raman and their extended applications are old and mature tools which allow non-contact and non-invasive investigation of molecular states in either solid or soft matters. The advancement in technology further pushes the possibility of using the molecular states for imaging; interaction and reaction can be visualized in vivo. In this talk, some examples of using spectroscopic methods in this respect will be discussed.
Raman spectroscopy is employed to address the question: what is the molecular signature that represents the “life stage” of a developing embryo? Among the complex Raman spectra of a developing mice embryo, the quality of the embryo which leads to successful development of the embryo can be quantified. In more general sense, the Raman signature of life can be generated.
Biocompatible nanomaterials open huge possibilities for drug conjugation and delivery. Combining the non-invasive nature of spectroscopic methods, image-guided drug delivery systems for preclinical applications can be realized. Various examples that has been realized in the cellular models. However conventional 2D cell culture model does not represent 3D structural of tissues and tumors, the 2D cellular models offer poor access to the efficiency of drug delivery. To address this, a 3D multicellular tumor spheroid (MCTS) of Human alveolar basal epithelial cell (A549) cellular model was developed to demonstrate the possibility of using nanodiamond (ND) for more efficient drug delivery and to evaluate the efficacy of ND-Drug complexes in cancer therapy.