多個驅動蛋白在擁擠的環境中通過分擔負載來加速貨物運輸
Communications Biology
Ya-Ting Huang, Michio Tomishige, Steven Gross, Pik-Yin Lai, and Yonggun Jun
Multiple kinesins speed up cargo transport in crowded environments by sharing load
這項研究表明多個驅動蛋白馬達如何在擁擠的細胞環境中沿著微管運輸貨物。我們使用非侵入性方法來量化活躍的馬達數量，並發現貨物的運動速度取決於參與運輸的馬達數量以及周圍環境內高分子的大小。結果表明，驅動蛋白產生的張力能在集體運輸中發揮作用。我們同時也有隨機模擬來佐證此一結論。該研究強調了此方法在研究馬達蛋白的參與機制方面的廣泛適用性，並還能用來探討擁擠環境中張力與驅動蛋白運輸貨物之間的複雜相互作用關係。
This study investigates how multiple kinesin motors transport cargo along microtubules in crowded environments. Using a non-invasive method to quantify the number of active motors, we find that cargo velocity depends on both motor number and the size of surrounding macromolecular obstacles. Their results suggest that kinesin-generated tension influences collective transport, a finding supported by stochastic simulations. The study highlights the method's broad applicability for studying motor engagement and the complex interplay between crowding tension and kinesin-driven cargo movement.