不只是能量分子

Molecular Cell, 73, 143-156 (2019)

Yingying Pu, Yingxing Li, Xin Jin, Tian Tian, Qi Ma, Ziyi Zhao, Ssu-yuan Lin, Zhanghua Chen, Binghui Li, Guang Yao, Mark C. Leake, Chien-Jung Lo, and Fan Bai

不只是能量分子

我們提出一個新概念,細菌的休眠深度,是由於不同ATP濃度降低引起的不同程度蛋白聚集所引起,此舉有助於細菌抗藥性

We introduced a concept of ‘‘dormancy depth’’ that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.