最新成果

不只是能量分子

More then the molecular currency

ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Yingying Pu, Yingxing Li, Xin Jin, Tian Tian, Qi Ma, Ziyi Zhao, Ssu-yuan Lin, Zhanghua Chen, Binghui Li, Guang Yao, Mark C. Leake, Chien-Jung Lo, and Fan Bai

Molecular Cell, 73, 143-156 (2019)

我們提出一個新概念,細菌的休眠深度,是由於不同ATP濃度降低引起的不同程度蛋白聚集所引起,此舉有助於細菌抗藥性。

We introduced a concept of ‘‘dormancy depth’’ that provides a unifying framework for understanding both persisters and viable
but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of
which facilitates bacterial drug tolerance.

ATP濃度降低引起細胞蛋白凝聚,進而導致細菌進入休眠狀態
ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance


X-Ray Photo-Desorption of H2O:CO:NH3 Circumstellar Ice Analogs: Gas-Phase Enrichment

A. Jiménez-Escobar, A. Ciaravella, C. Cecchi-Pestellini, C.-H. Huang, N.-E. Sie, Y.-J. Chen* and G. M. Muñoz Caro

Astrophysical Journal, 868, 73 (2018)

在太空環境中,複雜分子的生成機制被認為無法只經由氣體-氣體交互作用模型解釋其豐富的氣態含量。一般認為複雜分子是在星際冰中經由宇宙射線或是真空紫外光子照射下產生化學反應而生成,然而在極低溫環境下,這些複雜分子是如何不經由熱脫附過程而變成氣態分子一直是目前尚待了解的謎題。在此論文中,我們使用國家同步輻射研究中心所提供的soft X-ray觀測到C3H3NO, C4H5O, C4H7N等分子能夠在soft X-ray照射H2O+CO+NH3冰晶狀態下生成並脫附成為氣態分子。


超高強度單週期中紅外光脈衝產生 

Generation of relativistic single-cycle mid-infrared pulses

Relativistic single-cycle tunable infrared pulses generated from a tailored plasma density structure

Zan Nie, Chih-Hao Pai, Jianfei Hua, Chaojie Zhang, Yipeng Wu, Yang Wan, Fei Li, Jie Zhang, Zhi Cheng, Qianqian Su, Shuang Liu, Yue Ma, Xiaonan Ning, Yunxiao He, Wei Lu, Hsu-Hsin Chu, Jyhpyng Wang, Warren B. Mori, and Chan Joshi

Nature Photonics, 12, 489–494 (2018)

模擬研究利用電漿非線性相位調變產生單週期強場中紅外光脈衝,並進行實驗驗證。

By focusing ultrashort intense near-IR pulses into a tailored plasma density structure, relativistic single-cycle tunable infrared pulses can be generated from extreme frequency broadening.

電腦模擬電漿結構演化與單週期中紅外光脈衝生成

Simulation of plasma evolution and mid-IR pulse formation


離子通道 Betatron X 光光源研究 

Research of channel betatron x-rays

Enhancement of laser-driven betatron X-rays by a density-depressed plasma structure

Bo Guo, Zhi Cheng, Shuang Liu, Xiao Nan Ning, Jie Zhang, Chih-Hao Pai, Jianfei Hua, Hsu-hsin Chu, Jyhpyng Wang, and Wei Lu

Plasma Physics and Controlled Fusion, 61, 035003 (2019)

利用電漿結構密度變化增強雷射電子加速器中之 Betatron X 光輸出

Significant enhancement of betatron x-ray radiation from a laser-wakefield electron accelerator is done by inserting a density-depressed plasma structure.

雷射尾波電子加速器產生Betatron X 光架設圖

Experimental setup of Betatron x-ray radiation from laser-wakefield electron accelerator


高解析度 X 光相位對比攝影

High-resolution x-ray phase-contrast imaging

High-resolution phase-contrast imaging of biological specimens using a stable betatron X-ray source in the multiple-exposure mode

Bo Guo, Xiaohui Zhang, Jie Zhang, Jianfei Hua, Chih-Hao Pai, Chaojie Zhang, Hsu-Hsin Chu, Warren Mori, Chan Joshi, Jyhpyng Wang, and Wei Lu

Scientific Reports 9, 7796 (2019)

實驗架設圖與X光相位對比影像

Experimental setup and x-ray phase-contrast image


碳化鈧自由基近紅外雷射光譜

Near Infra-red laser spectroscopy of ScC Radical

A new 4-a 4Π electronic transition of ScC in the near Infra-red

Chiao-Wei Chen, Anthony J. Merer, and Yen-Chu Hsu

Journal of Molecular Spectroscopy 361, 40-46 (2019)

繼先前我們在可見光區的碳化鈧自由基光譜工作(Chen et. al., J. Chem.Phys. 149, 074302-1‒074302-15(2018) ),在近紅外光譜區找到一新系統。除了得到更精準的a4Π光譜常數外,提供在星雲中或太陽裡搜索ScC自由基的資訊。

Following our previous work of ScC radical (Chen et. al., J. Chem. Phys. 149, 074302-1‒074302-15 (2018) ), a new system in the near Infra-red region was found. Improved spectroscopic constants of a4Π were obtained, the line positions of this sytem are provided for searching the ScC radical in the interstellar cloud.

碳化鈧自由基的能階 及鍵長。箭號指出相關的躍遷。

The level diagram, term values and bond length of the ScC radical. The relevant transitions are shown

碳化鈧自由基的 4-a 4Π5/2 (1,0)近紅外光譜躍遷(部分), 黑色光譜為實驗結果,紅色譜線為譜帶模擬。

The near Infra-red spectrum of the 4-a 4Π5/2 (1,0) band of ScC radical (part). The spectrum colored in black is our experimental results, and the red lines are simulated band contours with a line width of 0.1 cm-1 narrower than our experimental conditions to show the details of this rotational structure.